Horizontal gene transfer among genomes: The complexity hypothesis

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Horizontal gene transfer among genomes: the complexity hypothesis.

Increasingly, studies of genes and genomes are indicating that considerable horizontal transfer has occurred between prokaryotes. Extensive horizontal transfer has occurred for operational genes (those involved in housekeeping), whereas informational genes (those involved in transcription, translation, and related processes) are seldomly horizontally transferred. Through phylogenetic analysis o...

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Bacteriophage genomic evolution has been largely characterized by rampant, promiscuous horizontal gene transfer involving both homologous and nonhomologous source DNA. This pattern has emerged through study of the tailed double-stranded DNA (dsDNA) phages and is based upon a sparse sampling of the enormous diversity of these phages. The single-stranded DNA phages of the family Microviridae, inc...

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The complexity hypothesis revisited: connectivity rather than function constitutes a barrier to horizontal gene transfer.

Horizontal gene transfer (HGT) is a prevalent and a highly important phenomenon in microbial species evolution. One of the important challenges in HGT research is to better understand the factors that determine the tendency of genes to be successfully transferred and retained in evolution (i.e., transferability). It was previously observed that transferability of genes depends on the cellular p...

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Detection of Horizontal Gene Transfer in Bacterial Genomes

Most bacterial genes were acquired by horizontal gene transfer (HGT) from other prokaryotic organisms instead of being inherited by continuous vertical descent from an ancient ancestor. HGT is generally believed to be a major factor in microbiology evolution, allowing rapid diversification and adaptation. In this paper, we artificially simulate HGT by inserting phage genes into bacterial genome...

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ژورنال

عنوان ژورنال: Proceedings of the National Academy of Sciences

سال: 1999

ISSN: 0027-8424,1091-6490

DOI: 10.1073/pnas.96.7.3801